Actions of Novel Angiotensin Receptor Blocking Drugs, Bisartans, Relevant for COVID-19 Therapy: Biased Agonism at Angiotensin Receptors and the Beneficial Effects of Neprilysin in the Renin Angiotensin System새로운 안지오텐신 수용체 차단 약물, 비사르탄, COVID-19 치료와 관련된 작용: 안지오텐신 수용체의 편향 작용 및 레닌 안지오텐신 시스템에서 네프릴리신의 유익한 효과Article Published on 2022-07-292022-09-11 Journal: Molecules [Category] COVID19(2023년), SARS, 바이오마커, [키워드] 3CLpro ACE2 Action activated activating active site Agonism ANG Ang II angiotensin angiotensin converting enzyme Angiotensin II angiotensin II receptor blockers (ARBS) angiotensin II receptors Angiotensin receptor blockers anionic ARB/NEP docking ARBs AT1 AT2 biased agonism binding biphenyl bisartans blocker blocking cells charge relay system (CRS) complementary COVID-19 COVID-19 virus DNA driven by edema Effect endopeptidase enzyme Evidence explained furin G protein Human genome humoral hypertension in silico inhibit inhibiting inverse agonist involved modulating molecular molecular dynamics Molecular dynamics (MD) mRNA neprilysin novel opposite peptide peptides Protein Pulmonary edema RAS receptor Receptor Blockers receptors Renin SARS-COV-2 infection Sartans. Screening Serine serine proteases switching System tetrazole this system Treatment Vasoactive viral entry Zinc [DOI] 10.3390/molecules27154854 PMC 바로가기 [Article Type] Article
Angiotensin type-1 receptor and ACE2 autoantibodies in Parkinson´s disease Research Published on 2022-06-142022-10-05 Journal: NPJ Parkinson's Disease [Category] 바이오마커, 신약개발, [키워드] ACE2 administration agonists angiotensin angiotensin-converting enzyme 2 antagonists ARBs AT1 autoantibodies autoantibody Autoimmunity blocker Brain candesartan cerebrospinal fluid contribute controls correlated CSF cultures Cytokines disease dysregulation Effect Factor increasingly Inflammatory inhibited involved mechanism member neurodegeneration Neuroinflammation observation Parkinson’s disease Patient patients progression RAS receptor renin-angiotensin system serum substantia suggested Support TNFSF14 Treatment Tumor [DOI] 10.1038/s41531-022-00340-9 [Article Type] Research
Control of CDH1/E-Cadherin Gene Expression and Release of a Soluble Form of E-Cadherin in SARS-CoV-2 Infected Caco-2 Intestinal Cells: Physiopathological Consequences for the Intestinal Forms of COVID-19SARS-CoV-2에 감염된 Caco-2 장 세포에서 CDH1/E-Cadherin 유전자 발현 및 가용성 형태의 E-Cadherin 방출 제어: COVID-19의 장 형태에 대한 생리병리학적 결과Article Published on 2022-05-042022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, 치료기술, 치료제, [키워드] 24 hour 24 hours 48 hour 48 hours ACE2 ACE2 mRNA Affect AT1 Caco-2 Caco-2 cell Caco-2 cells cadherin CDH1 Cell cell line cells Co-receptor connexin consequence contributing to Control COVID-19 Culture culture supernatant diarrhoea diarrhoea) digestive tract Disruption dissemination down-regulated dysregulation E-cadherin ENCODE epithelial exposure to expresse expression form Gastrointestinal symptom gastrointestinal symptoms gastrointestinal tract HCoV HCoV-OC43 HLA class I human ACE2 illnesses in viral induce infected with SARS-CoV-2 Infection intestinal intestinal barrier. intestinal cells intestinal tissue intranasal involved JAMA junctions leads membrane mRNA mRNA expression OC43 occludin pandemic Patient Physiopathological Post-infection Protein receptor receptor ACE2 Release remained reported respiratory respiratory tract SARS-CoV-2 SARS-COV-2 infection significant increase significantly lower Symptom the disease these symptoms TMPRSS2 Transcription transgenic mice Trigger Viral viral entry virus [DOI] 10.3389/fcimb.2022.798767 PMC 바로가기 [Article Type] Article
Non-invasive administration of AAV to target lung parenchymal cells and develop SARS-CoV-2-susceptible mice폐 실질 세포를 표적으로 하고 SARS-CoV-2-감수성 마우스를 개발하기 위한 AAV의 비침습적 투여Article Published on 2022-05-042022-09-11 Journal: Molecular therapy : the journal of the American So [Category] COVID19(2023년), SARS, 치료법, [키워드] AAV AAV2/8 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adeno-associated virus administration Alveolar Type II angiotensin AT1 AT2 can be used Cell cells coronavirus develop enzyme expression gene delivery gene knockout Gene therapy hACE2 human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 IFNAR immune immune function injected interferon receptor intratracheal administration intratracheal injection lung lung targeting. lung tissue lung tissues Lungs mice multiple lesion multiple lesions Non-invasive nucleocapsid protein parenchymal Protein pulmonary diseases receptor SARS-CoV-2 severe acute respiratory syndrome Coronavirus Signaling target technique Trachea transduced type I interferon viral titer virus [DOI] 10.1016/j.ymthe.2022.01.010 PMC 바로가기 [Article Type] Article
Fatal Neurodissemination and SARS-CoV-2 Tropism in K18-hACE2 Mice Is Only Partially Dependent on hACE2 ExpressionK18-hACE2 마우스의 치명적인 신경 보급 및 SARS-CoV-2 향성은 hACE2 발현에 부분적으로만 의존합니다Article Published on 2022-03-052022-09-11 Journal: Viruses [Category] SARS, 치료기술, [키워드] ACE2 ACE2 protein ACE2-expressing cell ACE2-expressing cells Analysis angiotensin animal animal models AT1 axonal transport blood-brain barrier Brain bronchiolar Cell Cohort comparative pathology COVID-19 Critical cytokeratin cytokeratin 18 promoter days post-infection death Dependent detectable dose ENhance epidemiological data euthanasia evaluated Evidence expressing expression hACE2 Human human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 hypothermia immunohistochemistry In situ hybridization in vivo in vivo imaging independent independent of inoculated intranasal K18-hACE2 Lineage Mild-to-moderate neuroepithelium Neuron neurons occur olfactory olfactory bulb olfactory neuroepithelium overexpression pathologic PFUs Pneumocytes Pneumonia portal question resulting SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pathogenesis spatiotemporal subsequent transgenic mice translational translational animal model Transmission transmission electron microscopy Transport tropism vasculature viral pathogenesis Viral pathogenesis. Viremia Virological [DOI] 10.3390/v14030535 PMC 바로가기 [Article Type] Article
Hypothesis: Emerging Roles for Aryl Hydrocarbon Receptor in Orchestrating CoV-2-Related Inflammation †Review Published on 2022-02-132022-10-31 Journal: Cells [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] ACE-2 adaptive angiotensin Apoptosis aryl Aryl hydrocarbon receptor AT1 binding boost build COVID-19 disease enzyme expression growth hydrocarbon IFN-I IL-6 immune tolerance Immunity Indolamine induce Inflammation Inflammatory Inflammatory response inflammatory state inhibitory innate response interferon Kynurenine limit management mechanism modulation Neutral pathogenic regulate respiratory Respiratory system role SARS-CoV-2 syndrome T cell target therapeutic target These data transporter Tryptophan type I [DOI] 10.3390/cells11040648 PMC 바로가기 [Article Type] Review
Subcellular Detection of SARS-CoV-2 RNA in Human Tissue Reveals Distinct Localization in Alveolar Type 2 Pneumocytes and Alveolar MacrophagesResearch Article Published on 2022-02-082022-10-29 Journal: mBio [Category] COVID-19, MERS, [키워드] AGER alveolar Alveolar macrophages amplification AT1 AT2 Autopsy caused Cell Cell culture cell line Cellular imaging coronavirus disease COVID-19 detection diagnostics Drug screening FFPE fixation fluorescent image analysis formalin Human human lung tissue human tissue identify infected patients infected with SARS-CoV-2 Infection Localization lung Lymph node macrophage marker Marco marker gene marker genes novel coronavirus SARS-CoV-2 observé ORF1a paraffin embedding pathology performed Placenta platform pneumocyte probe Region regions RNA RNA FISH SARS-CoV-2 SARS-CoV-2 RNA SFTPC Single Cell specimens subcellular subcellular localization subgenomic mRNAs tissue tissues Type viral life cycle Viral RNA widespread [DOI] 10.1128/mbio.03751-21 PMC 바로가기 [Article Type] Research Article
The Effects of ATIR Blocker on the Severity of COVID-19 in Hypertensive Inpatients and Virulence of SARS-CoV-2 in Hypertensive hACE2 Transgenic MiceOriginal Article Published on 2022-01-012022-10-29 Journal: Journal of Cardiovascular Translational Research [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] ACE2 ACE2 expression acute respiratory syndrome angiotensin converting enzyme 2 antihypertensive drugs AT1 AT1 receptor blocker AT1R ATIR Biomarker blocker cellular entry coronavirus Coronavirus disease 2019 COVID-19 COVID-19 patient CRP determine Effect enzyme hACE2 had no Heart injury higher risk hospitalized COVID-19 patient hypertension hypertensive hypertensive COVID-19 patient hypertensive patient IL-1 IL-6 inflammation marker Inpatient kidney outcome Post-infection receptor renin-angiotensin system required SARS-CoV-2 SARS-COV-2 infection serum severity supplementary material transgenic mice treated Treatment [DOI] 10.1007/s12265-021-10147-3 PMC 바로가기 [Article Type] Original Article
Expression of SARS‐CoV‐2 entry factors, electrolyte, and mineral transporters in different mouse intestinal epithelial cell typesOriginal Article Published on 2021-11-092022-10-28 Journal: Physiological Reports [Category] COVID-19, MERS, SARS, [키워드] abundantly expressed ACE2 Amino acid apical membrane AT1 basolateral calcium Cell cell type cells CFTR COVID‐19 diarrhea DRA Enterocyte enzyme epithelial cell type Evidence expressed expressing expression expression pattern Factor Factors goblet greater heterogeneous Hypothesis identity indicated infect Infection intestinal intestinal cell intestine iron mammalian mucosa multifunctional multifunctional protein pandemic Paneth cells protease provide receptor ACE2 required responsible SARS‐CoV‐2 SARS‐CoV‐2 infection SIT1 small intestine tested TMPRSS TMPRSS2 TMPRSS4 transmembrane Transport villus virus were expressed [DOI] 10.14814/phy2.15061 PMC 바로가기 [Article Type] Original Article
Development of ACE2 autoantibodies after SARS-CoV-2 infectionSARS-COV-2 감염 후 ACE2자가 항체의 발달Research Article Published on 2021-09-032022-08-13 Journal: PLoS ONE [Category] Biochemistry, SARS, 유전자 메커니즘, 진단, 치료기술, [키워드] abundance ACE2 ACE2 antibody ACE2 protein Activation Ang II angiotensin Angiotensin II Angiotensin-converting enzyme angiotensin-converting enzyme 2 Anti-spike antibodies antibody AT1 autoantibodies autoantibody cause cleave convalescent Cutoff decrease decreased activity detectable develop development enzyme enzyme activity exogenous ACE2 Hospitalized Hypothesis immune system implicated increase in Infection inhibit lead less mechanism Outpatient PASC Patient plasma positive PCR test proinflammatory Protein receptor resulting SARS-CoV-2 SARS-COV-2 infection serum soluble ACE2 Symptom tested threshold Trigger triggers [DOI] 10.1371/journal.pone.0257016 PMC 바로가기 [Article Type] Research Article